In the paper, researchers at the Weizmann Institute of Science in Israel describe what happened when they fed zero-calorie sweeteners, including saccharin, aspartame and sucralose, to mice.
"To our surprise, [the mice] developed glucose intolerance," Weizmann researcher Eran Elinav tells us.
Intrigued by the findings, Elinav and his colleague Eran Segal set out to determine if this might happen in people as well. : NPR
Artificial Sweeteners May Disrupt Body's Blood Sugar Controls - NYTimes.com
Artificial sweeteners linked to glucose intolerance - health - 17 September 2014 - New ScientistArtificial sweeteners may disrupt the body’s ability to regulate blood sugar, causing metabolic changes that can be a precursor to diabetes, researchers are reporting.That is “the very same condition that we often aim to prevent” by consuming sweeteners instead of sugar, said Dr. Eran Elinav, an immunologist at the Weizmann Institute of Science in Israel, at a news conference to discuss the findings.
Impaired glucose tolerance - Wikipedia, the free encyclopediaARTIFICIAL sweeteners can cause glucose intolerance in mice, and perhaps in humans, by altering gut bacteria, a series of experiments suggests. Although artificial sweeteners – among the world's most widely used food additives – are approved by most food regulation agencies as safe for humans, the researchers who led the work suggest that their use should be reassessed."The most shocking result is that the use of sweeteners aimed at preventing diabetes might actually be contributing to and possibly driving the epidemic that it aims to prevent," says Eran Elinav at the Weizmann Institute of Science in Rehovot, Israel, who co-supervised the work with his colleague Eran Segal.
Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede type 2 diabetes mellitus by many years. IGT is also a risk factor for mortality.